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Genesis Mission committee report outlines AI research priorities for biology, fusion and magnet sovereignty

The committee’s vice-chair shared an advisory report for the US Department of Energy’s Genesis Mission, focusing on AI-enabled biology, accelerated fusion energy and magnet sovereignty.

Pushmeet KohliPK
3 Sources, 11d ago, first seen 11d ago

TLDR

The Genesis Mission scientific committee’s vice-chair shared a report on how AI could accelerate discoveries in three priority areas: biology, fusion energy and magnet sovereignty. The vice-chair says the biology chapter calls for investment in measurement, modeling and manufacturing to help make biology more predictive and engineerable.

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3 Sources, first seen 11d ago

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3 Sources, first seen 11d ago

213 likes1 comments53 saves18 reposts

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Pushmeet Kohli@pushmeetEarlier this year I was invited by the U.S. Department of Energy’s Under Secretary for Science @dariogil to join the Genesis Mission scientific committee tasked to advise on DOE’s program to use AI to accelerate breakthroughs in Science as its Vice-Chair. I am happy to share the Science Advisory Committee report, "Genesis Mission Frameworks for AI-Accelerated National Breakthroughs," which shows how we can make transformative discoveries across three priority areas: AI-enabled biology, accelerated fusion energy, and magnet sovereignty. Creating this roadmap with the Genesis Subcommittee was a rewarding and collective effort. Together with co-authors Drew Endy and Lara Jehi, and with significant contributions from Ali Douraghy and others, I had the privilege of leading the chapter on: "Harnessing Biology at Digital Speed". In it, we lay out a national campaign to shift biology from an observational science into a predictive, engineerable discipline to advance human health, bioenergy, and national resilience. For decades, our ability to sequence and read DNA has outpaced our ability to interpret and design it. We called for key investment in the following three pillars to close this gap: AI-enabled measurement/sensing of biology through high-throughput systemic multiomics, in-cell visual proteomics, and structural dynamics. AI-enabled modeling and prediction of molecular mechanics and whole-cell causal simulation. AI-enabled manufacturing and design through next-generation biofoundries and predictive scale-up, closing this gap by treating bioreactor physics and cellular mechanics as one integrated computational problem. Realising AI’s potential across these national priority areas will require enormous collaboration, and the Genesis Mission is enabling this across national laboratories, universities, and industry. A sincere thank you to the committee and our contributors. Read the full report here: https://science.osti.gov/-/media/About/pdf/scac/reports/SCAC_Genesis_Mission_Frameworks_report.pdf11d
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    Pushmeet Kohli

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    Pushmeet Kohli@pushmeetEarlier this year I was invited by the U.S. Department of Energy’s Under Secretary for Science @dariogil to join the Genesis Mission scientific committee tasked to advise on DOE’s program to use AI to accelerate breakthroughs in Science as its Vice-Chair. I am happy to share the Science Advisory Committee report, "Genesis Mission Frameworks for AI-Accelerated National Breakthroughs," which shows how we can make transformative discoveries across three priority areas: AI-enabled biology, accelerated fusion energy, and magnet sovereignty. Creating this roadmap with the Genesis Subcommittee was a rewarding and collective effort. Together with co-authors Drew Endy and Lara Jehi, and with significant contributions from Ali Douraghy and others, I had the privilege of leading the chapter on: "Harnessing Biology at Digital Speed". In it, we lay out a national campaign to shift biology from an observational science into a predictive, engineerable discipline to advance human health, bioenergy, and national resilience. For decades, our ability to sequence and read DNA has outpaced our ability to interpret and design it. We called for key investment in the following three pillars to close this gap: AI-enabled measurement/sensing of biology through high-throughput systemic multiomics, in-cell visual proteomics, and structural dynamics. AI-enabled modeling and prediction of molecular mechanics and whole-cell causal simulation. AI-enabled manufacturing and design through next-generation biofoundries and predictive scale-up, closing this gap by treating bioreactor physics and cellular mechanics as one integrated computational problem. Realising AI’s potential across these national priority areas will require enormous collaboration, and the Genesis Mission is enabling this across national laboratories, universities, and industry. A sincere thank you to the committee and our contributors. Read the full report here: https://science.osti.gov/-/media/About/pdf/scac/reports/SCAC_Genesis_Mission_Frameworks_report.pdf11d
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