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Human tissue reportedly makes up over 90% of mouse cortical tissue by volume after transplants

A post describes Pașca’s Stanford lab transplanting human cortical organoids into mice whose own cortex never developed. It says the mice performed similarly to normal peers by six months.

Johanna FarrimondJF
1 Source, 24d ago, first seen 24d ago

TLDR

According to a post, Pașca’s lab at Stanford engineered mice whose own cortex never developed, then transplanted human cortical organoids into the empty space. The post says more than 90% of cortical tissue by volume was human within three months. By six months, it says, the mice performed similarly to normal peers.

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1 Source, first seen 24d ago

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1 Source, first seen 24d ago

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Johanna Farrimond@jjfarrimondPașca's lab at Stanford engineered mice whose own cortex never developed. Then transplanted human cortical organoids into the empty space. Within three months, more than 90% of the cortical tissue by volume was human. By six months, the mice performed similarly to normal peers.24d
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    Stanford

    1 Source

    Johanna Farrimond@jjfarrimondPașca's lab at Stanford engineered mice whose own cortex never developed. Then transplanted human cortical organoids into the empty space. Within three months, more than 90% of the cortical tissue by volume was human. By six months, the mice performed similarly to normal peers.24d
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